Polynucleotides are a lot more than just another injectable, representing a breakthrough in bio-revitalisation. Composed of DNA chains, these nucleotides work at a cellular level to repair damaged skin, stimulate collagen and elastin production, and deeply hydrate. As leading aesthetic expert Dr. Maryam Zamani explains, polynucleotides are “safe on all skin types and capable of being used alone or in combination with other treatments for a myriad of skin improvements.”

Unlike fillers, which add volume, polynucleotides help detox, hydrate, and improve skin tone by stimulating fibroblasts – the cells responsible for collagen production. They stabilise pigmentation, reduce fine lines, and bring about a firmer, smoother complexion. Simply put, they are designed to boost your skin’s health from the inside out, giving it long-lasting vitality without the risk of over-plumping or unnatural results.

Polynucleotides work subtly but effectively, providing long-term improvement in the skin’s tone, texture, and elasticity. Dr. Zamani explains, “Polynucleotides encourage cell growth, improve skin elasticity, hydrate the skin, reduce inflammation, and target hyperpigmentation.” One of its key benefits? It treats delicate areas, like the under-eye, that fillers often can’t address without adding unwanted volume.

Over at Thérapie Clinic, Dr. Farah Kanji has seen brilliant results, especially for those who aren’t a good candidate for eye filler. “I’ve been saying to my clients for the last few years that a treatment will come along that will be a game-changer for the eye area, and this is it.”

The treatment is especially effective for those looking to rejuvenate the periorbital area – think reduced puffiness, improved hydration, and smoothed fine lines. Rather than creating fullness, polynucleotides help to contour and firm through collagen stimulation. And the best part? Results last. After two to three sessions spaced a few weeks apart, expect to see your best skin 4-6 weeks after the final treatment, with results lasting up to six months.

Polynucleotides stand out because they’re universally suitable. “Unlike under-eye fillers, polynucleotides are safe for all skin tones,” says Dr. Zamani, making them an excellent choice for anyone, no matter their skin type or complexion. Whether you’re looking to prevent signs of aging or treat existing concerns, polynucleotides offer a versatile solution for both younger and more mature skin.

The beauty of this treatment lies in its adaptability. Whether it’s used on the face, neck, or décolletage—or even combined with other treatments like lasers or peels—it fits seamlessly into a variety of skincare regimes, offering enhanced results across the board. Brands like Plinest have also been clever and have tailored products for the eye, an HA/Polynucleotide version for the face (which gives the glow of profhilo but the benefits of polynucleotides) and another for the neck area.

Anaesthetic cream is applied to the area being treatment before a fine needle or cannula is used to deliver the product into the skin. Though there may be slight discomfort as the solution is injected, it quickly subsides. Dr. Zamani reassures, “As with all injections, there’s the potential for swelling or bruising, particularly in delicate areas like the under-eye, but any social downtime typically lasts a maximum of 24 to 72 hours.”

We tried the treatment at Thérapie clinic, which involved using a cannula for the eyes and small injections for the rest of the face and next. There was mild redness immediately afterwards that subsided within a couple of hours and a small neck bruise that was easy to hide with make-up. This short recovery window makes polynucleotides an ideal choice for those who want noticeable results without a major interruption to their schedule. With minimal discomfort and downtime, it’s a small trade-off for the lasting benefits of smoother, firmer skin.

Given its rising popularity, you’ll want to ensure you’re booking with the best in the industry. These clinics offer polynucleotide treatments at the height of expertise and luxury:

• Thérapie Clinic
  The nation’s leading aesthetic clinic group, Therapie Clinic makes polynucleotide treatments widely accessible across all 70 of its locations in the UK and Ireland. Polynucleotides are fast becoming one of their most popular treatments and we saw the brilliant Dr. Farah Kanji at Thérapie Westfield White City.
• Dr. Maryam Zamani
  A highly respected name in London’s aesthetic scene, Dr. Zamani is known for her expertise in the under-eye area, using polynucleotides as an alternative to traditional fillers. Her clinic offers bespoke, personalised treatments with natural and rejuvenating results.
• Montrose London
  Tucked away in the heart of Knightsbridge, Montrose London combines high-tech treatments with a luxurious, calming atmosphere. Known for its discreet clientele and premium service, Montrose is the go-to for those seeking both privacy and perfection.
• Ardour Clinic
  One of our favourite aesthetic doctors, Dr. Paris has recently co-founded the Ardour Clinic in Marylebone, alongside wellness expert Anna Miller. With a background in maxillofacial surgery, Dr. Paris is brilliant at tailoring polynucleotide treatments to make you look like your best, most refreshed self.